The effect of open-source software technologies in health-tech startups

Abstract. The research investigates how open-source technology improves product efficiency and identifies the challenges encountered by startups when introducing open-source software technologies in the startups. The semi-structured interviews were conducted with healthcare startups based in Oulu. Thematic data analysis was performed to analyse the collected data and identified common themes and sub-themes to the research objective

Oil palm leaf fibre and its suitability for paper-based products

Due to the shortage of wood as origin materials for paper-based production, agro-residue materials have been explored in the quest of finding the best alternative fibre. Oil palm leaf (OPL) is one of agro-residue that has potential due to its comparable characteristics with wood fibre. Studies on chemical compositions, fibre morphology, and mechanical property of OPL have been carried out aiming to evaluate its potential as a substitute raw material for pulp and paper-based production. The chemical compositions were analysed according to the TAPPI standard, Kurscher-Hoffner and chlorite methods accordingly. The mechanical property (tensile, tearing and bursting strengths) were determined as described in TAPPI test methods. Fibre dimensions were determined using Franklin method and analysed under the optical microscope. The content of cellulose in the OPL is determined to be 43.8%. Although, this result is lower than wood fibre (53%), OPL has higher hemicellulose content (36.4%) than the wood fibre (27.5%). In addition, the lignin content (19.7%) of OPL is in the low range of those in wood resources (18 - 25%). These parameters are important components to produce good quality pulp and will provide high mechanical strength of the paper-based products. The measured fibre length of oil palm leaf (1.13 mm) is shorter than the wood fibre (1.90 mm). Meanwhile, the mechanical property of OPL showed lower indexes than wood resources, however, tear (1.80 mN.m2/g) and burst (0.95 kPa.m2/g) indexes of OPL are higher than other published and successful wood resources (Eucalyptus). Based on the analyses, the oil palm leaf is indeed a suitable alternative of raw material for pulp and paper-based industries

Development and Operation Analysis of Spectrum Monitoring Subsystem 2.4–2.5 GHz Range

The paper presents a substantiation of the effectiveness of IEEE 802.11 wireless network analysis subsystem implementation using miniature spectrum analyzers. Also it was given an overview of firmware work scheme, development process of trial versions, monitoring system development approaches, current development stage, infrastructure for research system, reliability and scan check, our system design and hardware implementation, future work, etc. Paper also provides technical solutions on automation, optimal algorithms searching, errors correcting, organizing software according to the Model-View-Controller scheme, harmonizing data exchange protocols, storing and presenting the obtained results

A Phytochemical Analysis, Microbial Evaluation and Molecular Interaction of Major Compounds of Centaurea bruguieriana Using HPLC-Spectrophotometric Analysis and Molecular Docking

Centaurea is one of the most important genera within the family Asteraceae. An investigation of the phytochemical composition of Centaurea bruguieriana using Gas-Chromatography coupled to Mass spectrometry (GC-MS) was performed. Antimicrobial activity was evaluated using the minimum inhibitory concentration method (MIC) and validated by molecular docking for the major compounds of the most active fraction (1,10-di-epi-cubenol and methyl 8-oxooctanoate) of C. bruguieriana against three bacterial receptors (TyrRS, DNA gyrase, and dihydrofolate reductase (DHFR)). Evaluation of antioxidant activity was conducted using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. High-performance liquid chromatography (HPLC) was used to identify and quantify the contents of major compounds from ethyl acetate fraction (luteolin 7-O-glucoside, chlorogenic acid, kaempferol and isorhamnetin). The antimicrobial activity test showed that the chloroform fraction was more active against all microbial strains. The results of the molecular docking of two major compounds from chloroform fraction showed that good affinities were made between 1,10-di-epi-cubenol and the three selected receptors (TyrRs: −6.0 Kcal/mol against −8.2 Kcal/mol obtained with clorobiocin (standard); DNA gyrase: −6.6 Kcal/mol against −9.1 Kcal/mole obtained with clorobiocin; DHFR: −7.4 Kcal/mol against −6.3 Kcal/mol obtained with SCHEMBL2181345 Standard). Antioxidant evaluation showed that the ethyl acetate fraction was the most active fraction in DPPH (IC50 49.4 µg/mL) and ABTS (IC50 52.8 µg/mL) models. HPLC results showed the contents of luteolin 7-O-glucoside (7.4 µg/mg), and chlorogenic acid (3.2 µg/mg). Our study demonstrated that C. bruguierana is a promising source of bioactive compounds

A Phytochemical Analysis, Microbial Evaluation and Molecular Interaction of Major Compounds of Centaurea bruguieriana Using HPLC-Spectrophotometric Analysis and Molecular Docking

Centaurea is one of the most important genera within the family Asteraceae. An investigation of the phytochemical composition of Centaurea bruguieriana using Gas-Chromatography coupled to Mass spectrometry (GC-MS) was performed. Antimicrobial activity was evaluated using the minimum inhibitory concentration method (MIC) and validated by molecular docking for the major compounds of the most active fraction (1,10-di-epi-cubenol and methyl 8-oxooctanoate) of C. bruguieriana against three bacterial receptors (TyrRS, DNA gyrase, and dihydrofolate reductase (DHFR)). Evaluation of antioxidant activity was conducted using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. High-performance liquid chromatography (HPLC) was used to identify and quantify the contents of major compounds from ethyl acetate fraction (luteolin 7-O-glucoside, chlorogenic acid, kaempferol and isorhamnetin). The antimicrobial activity test showed that the chloroform fraction was more active against all microbial strains. The results of the molecular docking of two major compounds from chloroform fraction showed that good affinities were made between 1,10-di-epi-cubenol and the three selected receptors (TyrRs: −6.0 Kcal/mol against −8.2 Kcal/mol obtained with clorobiocin (standard); DNA gyrase: −6.6 Kcal/mol against −9.1 Kcal/mole obtained with clorobiocin; DHFR: −7.4 Kcal/mol against −6.3 Kcal/mol obtained with SCHEMBL2181345 Standard). Antioxidant evaluation showed that the ethyl acetate fraction was the most active fraction in DPPH (IC50 49.4 µg/mL) and ABTS (IC50 52.8 µg/mL) models. HPLC results showed the contents of luteolin 7-O-glucoside (7.4 µg/mg), and chlorogenic acid (3.2 µg/mg). Our study demonstrated that C. bruguierana is a promising source of bioactive compounds

N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS

<b>Aims:</b>To test whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) was independently associated with, and improved the prediction of, cardiovascular disease (CVD) in a primary prevention cohort. <b>Methods and results:</b> In the West of Scotland Coronary Prevention Study (WOSCOPS), a cohort of middle-aged men with hypercholesterolaemia at a moderate risk of CVD, we related the baseline NT-proBNP (geometric mean 28 pg/mL) in 4801 men to the risk of CVD over 15 years during which 1690 experienced CVD events. Taking into account the competing risk of non-CVD death, NT-proBNP was associated with an increased risk of all CVD [HR: 1.17 (95% CI: 1.11–1.23) per standard deviation increase in log NT-proBNP] after adjustment for classical and clinical cardiovascular risk factors plus C-reactive protein. N-terminal pro-B-type natriuretic peptide was more strongly related to the risk of fatal [HR: 1.34 (95% CI: 1.19–1.52)] than non-fatal CVD [HR: 1.17 (95% CI: 1.10–1.24)] (P= 0.022). The addition of NT-proBNP to traditional risk factors improved the C-index (+0.013; P < 0.001). The continuous net reclassification index improved with the addition of NT-proBNP by 19.8% (95% CI: 13.6–25.9%) compared with 9.8% (95% CI: 4.2–15.6%) with the addition of C-reactive protein. N-terminal pro-B-type natriuretic peptide correctly reclassified 14.7% of events, whereas C-reactive protein correctly reclassified 3.4% of events. Results were similar in the 4128 men without evidence of angina, nitrate prescription, minor ECG abnormalities, or prior cerebrovascular disease. <b>Conclusion:</b> N-terminal pro-B-type natriuretic peptide predicts CVD events in men without clinical evidence of CHD, angina, or history of stroke, and appears related more strongly to the risk for fatal events. N-terminal pro-B-type natriuretic peptide also provides moderate risk discrimination, in excess of that provided by the measurement of C-reactive protein

Saving investment correlation in South Asia - a panel approach

Using Fixed Effect, Random Effect and between or CS models, we find that there is low correlation between saving and investment in Bangladesh, India, Pakistan, Sri Lanka and Nepal. However this result does not necessarily imply high capital mobility in these countries as capital mobility is influenced by other factors also such as the economic size, differences in financial structure across countries, fiscal policy coordination etc

Low complexity DCO-FBMC visible light communication system

Filter Bank Multicarrier (FBMC) is a new waveform candidate in the visible light communication system (VLC). FBMC is a distinctive kind of multi-carrier modulation that can be regarded as an alternative to orthogonal frequency Division Multicarrier (OFDM) with CP (cyclic prefix). DCO-FBMC (DC-bias optical FBMC) has recently been used in VLC, because it overcomes all defects in the optical-OFDM system and has high spectral efficiency. but at the same time the traditional DCO-FBMC suffers from high complexity due to the use of Hermitian Symmetry for real signal, by using 2N-point subcarrier IFFT (Inverse Fast Fourier Transformer) in the modulator, and the output is N-point subcarrier FFT (Fast Fourier Transform) in the demodulator. In this paper, for the first time, the possibility of minimizing complexity and generating a real signal without the use of Hermitian Symmetry or any other technique has been verified. The proposed technology provides 50% of the size of the IFFT / FFT and this results in a significant reduction in power consumption and occupied chip area

First and second-order dust-ion-acoustic rogue waves in non-thermal plasma

A nonlinear Schr\"{o}dinger equation (NLSE) has been derived by employing reductive perturbation method for investigating the modulational instability of dust-ion-acoustic waves (DIAWs) in a four-component plasma having stationary negatively charged dust grains, inertial warm ions, and inertialess non-thermal electrons and positrons. It is observed that under consideration, the plasma system supports both modulationally stable and unstable domains, which are determined by the sign of the dispersive and nonlinear coefficients of NLSE, of the DIAWs. It is also found that the nonlinearity as well as the height and width of the first and second-order rogue waves increases with the non-thermality of electron and positron. The relevancy of our present investigation to the observations in space plasmas is pinpointed.Comment: 5 pages, 5 figure